Ciprofloxacin hydrochloride exhibits poor flow properties and compressibility. To prepare crystal agglomerates, an acetone: dichloromethane: water system was used, where dichloromethane acted as bridging liquid, water and acetone as good and bad solvents respectively. The proportion of this solvent system was selected from ternary phase diagram. Polyvinyl Pyrrolidone was also used along with drug solution in water, to improve agglomerate strength. The effect of agitation speed, time of agitation and temperature of system was also determined. The agglomerates were characterized by Infra-Red spectroscopy, TLC, X-ray diffraction, differential scanning calorimetry and scanning electron microscopy. Micromeritic properties like true, bulk and tapped densities, angle of repose, Carr’s index, particle size and spherical index were determined. Crystal agglomerates of Ciprofloxacin hydrochloride showed improvement in flowability, packability and compressibility. The results of micromeritic properties and Heckel’s analysis confirmed an improvement in compressibility of crystal agglomerates [1, 3] when compared to plain Ciprofloxacin Hydrochloride. The resultant agglomerates was directly compressed into tablets and evaluated for tablet properties. Stability studies of these tablets were also carried out for a period of four weeks. Directly compressible agglomerates of Ciprofloxacin Hydrochloride, having excellent flow properties and compressibility was prepared by spherical crystallization technique.
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